製品番号: HY-P0078

TRAP-6

(別名: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6; トロンビンレセプターアクチベーターペプチド6)

6 Cited Publications

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.

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純度: 99.98%
CAS 番号: 141136-83-6
分子式: C₃₄H₅₆N₁₀O₉
分子量:748.87

保管条件:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

TRAP-6 構造式

CAS 番号: 141136-83-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (6)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

PAR1

96 nM (IC₅₀)

PAR1

Protease Activated Receptor (PAR) アイソフォーム固有の製品をすべて表示 :

体外実験

TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1^[1].
TRAP-6 (0.01-10 μM; 30 min) activates human platelets^[1].
TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 141136-83-6
性状 Solid
分子量 748.87
分子式 C₃₄H₅₆N₁₀O₉
Color White to off-white
別名

PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6; トロンビンレセプターアクチベーターペプチド6
配列

Ser-Phe-Leu-Leu-Arg-Asn
シーケンスの短縮

SFLLRN
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

All ELISABio/Physico-chemical AssayIFWB

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Journal Impact Factor

Phytomedicine

Formononetin attenuates myocardial ischemia/reperfusion injury by regulating neutrophil extracellular traps formation and platelet activation via platelet CD36. [Abstract]

2025 Jun:141:156736. PMID: 40250000

TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jun:141:156736. [Abstract]

Trap-6 (25 μM) significantly increased the degree of platelet activation.

TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jun:141:156736. [Abstract]

Immunofluorescence of platelets and neutrophil extracellular traps (NETs) (MPO, CitH3) (scale bar, 40 μm, n = 3). The results showed that significant NETs formation was observed in both the C+Trap-6 (25 μM) group and the C+Trap-6+FMN+CD36 group. #p < 0.05 vs Sham group; ##p < 0.01 vs Sham group; ###p < 0.001 vs Sham group; *p < 0.05 vs MI/R group, **p < 0.01 vs MI/R group, ***p < 0.001 vs MI/R group; $p < 0.05 vs C+Trap-6+FMN group; $$$p < 0.001 vs C+Trap-6+FMN group.
Phytomedicine

Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk. [Abstract]

2022 Sep:104:154271. PMID: 35777120

TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Sep:104:154271. [Abstract]

Influence of DSS on aggregation of platelets induced by TRAP-6 (2 μM). n = 3.
J Thromb Haemost

Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface. [Abstract]

2025 Mar 26:S1538-7836(25)00200-4. PMID: 40154792

TRAP-6 purchased from MedChemExpress. Usage Cited in: J Thromb Haemost. 2025 Mar 26:S1538-7836(25)00200-4. [Abstract]

To test the effect of LAIR2 on collagen-induced platelet activation, platelets from pregnant women were stimulated with either collagen type I (COL1) or TRAP6, which were either preincubated with or without rhLAIR2 (G). Subsequent aggregometry showed that preincubation with LAIR2 inhibited platelet activation induced by COL1 but not TRAP-6 (50 μM; 30 min)(H).
J Thromb Haemost

Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity. [Abstract]

2024 May;22(5):1463-1474. PMID: 38266680
Mol Med Rep

Vorapaxar stabilizes permeability of the endothelial barrier under cholesterol stimulation via the AKT/JNK and NF‑κB signaling pathways. [Abstract]

2019 Jun;19(6):5291-5300. PMID: 31059055

TRAP-6 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Jun;19(6):5291-5300. [Abstract]

Detection of expression levels of p‑AKT, AKT, p‑JNK, JNK and NF‑κB using western blotting. Groups: NC, negative control group; CH, a cholesterol stimulation group; CH+T, cholesterol stimulation with TRAP‑6 treatment group; CH+V, cholesterol stimulation with vorapaxar treatment group.
Thromb Res

A novel GATA1 variant p.G229D causing the defect of procoagulant platelet formation. [Abstract]

2024 Feb:234:39-50. PMID: 38159323

溶剤 & 溶解度

体外:

H₂O : 25 mg/mL (33.38 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3353 mL

6.6767 mL

13.3535 mL

5 mM

0.2671 mL

1.3353 mL

2.6707 mL

10 mM

0.1335 mL

0.6677 mL

1.3353 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. [Content Brief]

[2]. Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82(1):103-6. [Content Brief]

[3]. Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349(2-3):237-43. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.3353 mL	6.6767 mL	13.3535 mL	33.3836 mL
	5 mM	0.2671 mL	1.3353 mL	2.6707 mL	6.6767 mL
	10 mM	0.1335 mL	0.6677 mL	1.3353 mL	3.3384 mL
	15 mM	0.0890 mL	0.4451 mL	0.8902 mL	2.2256 mL
	20 mM	0.0668 mL	0.3338 mL	0.6677 mL	1.6692 mL
	25 mM	0.0534 mL	0.2671 mL	0.5341 mL	1.3353 mL
	30 mM	0.0445 mL	0.2226 mL	0.4451 mL	1.1128 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TRAP-6

6 Cited Publications

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TRAP-6

PAR-4 Agonist Peptide, amide

Vorapaxar

Protease-Activated Receptor-2, amide

SLIGRL-NH2

Parmodulin 2

PAR-4 Agonist Peptide, amide TFA

Tamoxifen

Arg-Gly-Asp-Ser

Adenosine 5'-diphosphate

TFLLR-NH2

TFLLR-NH2TFA

Forskolin

MedChemExpress（MCE）の使用を引用している文献 TRAP-6

Protease Activated Receptor (PAR) アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (6)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

TRAP-6

PAR-4 Agonist Peptide, amide

Vorapaxar

Protease-Activated Receptor-2, amide

SLIGRL-NH2

Parmodulin 2

PAR-4 Agonist Peptide, amide TFA

Tamoxifen

Arg-Gly-Asp-Ser

Adenosine 5'-diphosphate

TFLLR-NH2

TFLLR-NH2TFA

Forskolin

MedChemExpress（MCE）の使用を引用している文献 TRAP-6

Protease Activated Receptor (PAR) アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (6)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

TRAP-6 関連分類

HY-P0078 関連分類

Bioz