FAP Substrate
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L-Ala-BPA
0 ImagesL-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT).
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ARI-3144
0 ImagesARI-3144 is a fluorogenic substrate for FAP with a FAP/PREP selectivity index of 15, and is processed by prolyl oligopeptidase (PREP).
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Faridoxorubicin
0 Images製品番号: HY-177083CAS 番号: 1841402-73-0別名: AVA-6000Faridoxorubicin (AVA-6000) is a FAP-activated chemotherapeutic prodrug. Faridoxorubicin undergoes selective hydrolysis by FAP, while it is resistant to cleavage by related mammalian peptidases and members of the DASH subfamily. Faridoxorubicin acts as a tumor growth inhibitor, reducing tumor volume and prolonging survival in in vivo models and PDX models with high FAP expression. Faridoxorubicin can be used in the research of osteosarcoma and sarcoma.
