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製品番号: HY-12287

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YH239-EE

Name: YH239-EE
Brand: MedChemExpress
SKU: HY-12287
Price: 78.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.

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純度 : 99.50%
CAS 番号: 1364488-67-4
分子式: C₂₅H₂₇Cl₂N₃O₄
分子量:504.41

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

YH239-EE 構造式

CAS 番号: 1364488-67-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent. IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).

化学情報

CAS 番号 1364488-67-4
性状 Solid
分子量 504.41
分子式 C₂₅H₂₇Cl₂N₃O₄
Color White to off-white
SMILES

O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Viruses

Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses. [Abstract]

2023 Feb 28;15(3):655. PMID: 36992362

溶剤 & 溶解度

体外:

DMSO : ≥ 55 mg/mL (109.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9825 mL

9.9126 mL

19.8251 mL

5 mM

0.3965 mL

1.9825 mL

3.9650 mL

10 mM

0.1983 mL

0.9913 mL

1.9825 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Huang Y, et al. Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem Biol. 2014 Mar 21;9(3):802-11. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9825 mL	9.9126 mL	19.8251 mL	49.5629 mL
	5 mM	0.3965 mL	1.9825 mL	3.9650 mL	9.9126 mL
	10 mM	0.1983 mL	0.9913 mL	1.9825 mL	4.9563 mL
	15 mM	0.1322 mL	0.6608 mL	1.3217 mL	3.3042 mL
	20 mM	0.0991 mL	0.4956 mL	0.9913 mL	2.4781 mL
	25 mM	0.0793 mL	0.3965 mL	0.7930 mL	1.9825 mL
	30 mM	0.0661 mL	0.3304 mL	0.6608 mL	1.6521 mL
	40 mM	0.0496 mL	0.2478 mL	0.4956 mL	1.2391 mL
	50 mM	0.0397 mL	0.1983 mL	0.3965 mL	0.9913 mL
	60 mM	0.0330 mL	0.1652 mL	0.3304 mL	0.8260 mL
	80 mM	0.0248 mL	0.1239 mL	0.2478 mL	0.6195 mL
	100 mM	0.0198 mL	0.0991 mL	0.1983 mL	0.4956 mL

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Keywords

YH239-EE

1 Cited Publications

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YH239-EE

MedChemExpress（MCE）の使用を引用している文献 YH239-EE

生物活性

製品説明

化学情報

Publications (1)

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

Keywords

最近チェックした製品

YH239-EE

MedChemExpress（MCE）の使用を引用している文献 YH239-EE

生物活性

製品説明

化学情報

Publications (1)

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

YH239-EE 関連分類

HY-12287 関連分類

Bioz

Keywords

最近チェックした製品