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製品番号: HY-163149

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AB-452

AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model.

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CAS 番号: 2226178-35-2
分子式: C₂₁H₂₆N₂O₆
分子量:402.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AB-452 構造式

CAS 番号: 2226178-35-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	EC₅₀	3 nM Compound: (S)-20; AB-452	Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBeAg level measured after 16 days by ELISA Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBeAg level measured after 16 days by ELISA	[PMID: 38190324]
Hepatocyte	EC₅₀	3 nM Compound: (S)-20; AB-452	Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBsAg level measured after 16 days by ELISA Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBsAg level measured after 16 days by ELISA	[PMID: 38190324]
Hepatocyte	EC₅₀	3 nM Compound: (S)-20; AB-452	Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBV DNA level measured after 16 days by ELISA Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBV DNA level measured after 16 days by ELISA	[PMID: 38190324]
HepG2 2.2.15	CC₅₀	>50 μM Compound: (S)-20; AB-452	Cytotoxicity against human HepG2.2.15 cells by Cell-titer Glo luminescent assay Cytotoxicity against human HepG2.2.15 cells by Cell-titer Glo luminescent assay	[PMID: 38190324]
HepG2 2.2.15	EC₅₀	0.001 μM Compound: (S)-20; AB-452	Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg level incubated for 6 days by microplate-based chemiluminescence immunoassay Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg level incubated for 6 days by microplate-based chemiluminescence immunoassay	[PMID: 38190324]

化学情報

CAS 番号 2226178-35-2
分子量 402.44
分子式 C₂₁H₂₆N₂O₆
SMILES

CC([C@H]1N2C(C3=NC(OC)=C(OCCCOC)C=C3C1)=CC(C(C(O)=O)=C2)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Dimitar Gotchev, et al. Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer. J. Med. Chem. January 8, 2024.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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