ABCA1 inducer 3
ABCA1 inducer 3 (Compound 85) is an orally active ABCA1 inducer and lipid-modulating agent. ABCA1 inducer 3 increases ABCA1 expression. ABCA1 inducer 3 upregulates hepatic Abcg5 and Abcg8 mRNA expression. ABCA1 inducer 3 promotes cholesterol efflux. ABCA1 inducer 3 improves hyperlipidemia.
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- CAS 番号: 2681270-30-2
- 分子式: C18H14BrCl2N3O4S2
- 分子量:551.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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ABCA1 |
ABCA1 inducer 3 (10 μM; 24 h) potently upregulates ABCA1 in ABCA1p-LUC HepG2 cells, achieving a 578% upregulation rate and an EC50 of 0.15 μM[1].
ABCA1 inducer 3 (2.5-10 μM; 24 h) induces moderate, dose-dependent upregulation of Abca1 mRNA expression in RAW264.7 macrophages[1].
ABCA1 inducer 3 (10 μM; 18 h co-treated with 22-NBD cholesterol, 6 h with ApoA-I) promotes cholesterol efflux from RAW264.7 macrophages, as shown by reduced intracellular 22-NBD cholesterol fluorescence[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Golden Syrian hamsters[1]
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Dosage:50 mg/day
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Administration:p.o.; daily; 8 weeks
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Result:Reduced plasma triglyceride (TG) levels by 33% and plasma total cholesterol (TC) levels by 22% compared to the high-fat diet model group, with no significant impact on low-density lipoprotein cholesterol (LDL-C) or high-density lipoprotein cholesterol (HDL-C) levels.
Decreased Oil Red O-positive lipid areas by over 40% compared to the model group.
Upregulated hepatic Abca1 mRNA expression to approximately 1.9-fold that of the normal control group, and restored ABCA1 protein expression to levels significantly higher than the model group.
Significantly upregulated hepatic Abcg5 and Abcg8 mRNA expression.
Showed no significant effects on aspartate aminotransferase (AST), alanine aminotransferase (ALT), plasma glucose, bile acids, or direct bilirubin levels versus the model group.
化学情報
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CAS 番号 2681270-30-2
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分子量 551.26
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分子式 C18H14BrCl2N3O4S2
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SMILES
O=C(C1=CC(Br)=C2N=C(SC2=C1)N3CCN(CC3)S(=O)(C4=CC=CC(Cl)=C4Cl)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ABCA1 inducer 3 関連分類
HY-181520 関連分類
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