ACHM-025
Based on 1 Customer Validation
ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.06%
- CAS 番号: 2377718-85-7
- 分子式: C17H28N4O10S3
- 分子量:544.62
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
ACHM-025 exhibits potent cytotoxic activity only against AKR1C3-overexpressing HCT116 cells with an IC50 of 0.03 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NOD/SCID or NSG mice inoculated with chemoresistant T-ALL PDX (ALL-31)[1]
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Dosage:25 mg/kg
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Administration:Intraperitoneally injection, at days 0, 7, 14
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Result:Reduced the proportion of human leukemia cells in peripheral blood to <1% and maintained it for more than 10 weeks.
Extended the median event-free survival (EFS) from 16.7 days to >332 days.
Showed no relapse within the >300-day observation period, and no leukemia cells are detected in organs such as bone marrow and spleen after dissection, achieving functional cure in 5 mice.
化学情報
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CAS 番号 2377718-85-7
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性状 Solid
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分子量 544.62
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分子式 C17H28N4O10S3
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Color Light yellow to yellow
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SMILES
O=S(C1=CC([N+]([O-])=O)=CC=C1N(CCOS(=O)(C)=O)CCOS(=O)(C)=O)(N2CCN(CC2)C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 50 mg/mL (91.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8361 mL | 9.1807 mL | 18.3614 mL | 45.9036 mL |
| 5 mM | 0.3672 mL | 1.8361 mL | 3.6723 mL | 9.1807 mL | |
| 10 mM | 0.1836 mL | 0.9181 mL | 1.8361 mL | 4.5904 mL | |
| 15 mM | 0.1224 mL | 0.6120 mL | 1.2241 mL | 3.0602 mL | |
| 20 mM | 0.0918 mL | 0.4590 mL | 0.9181 mL | 2.2952 mL | |
| 25 mM | 0.0734 mL | 0.3672 mL | 0.7345 mL | 1.8361 mL | |
| 30 mM | 0.0612 mL | 0.3060 mL | 0.6120 mL | 1.5301 mL | |
| 40 mM | 0.0459 mL | 0.2295 mL | 0.4590 mL | 1.1476 mL | |
| 50 mM | 0.0367 mL | 0.1836 mL | 0.3672 mL | 0.9181 mL | |
| 60 mM | 0.0306 mL | 0.1530 mL | 0.3060 mL | 0.7651 mL | |
| 80 mM | 0.0230 mL | 0.1148 mL | 0.2295 mL | 0.5738 mL |
ACHM-025 関連分類
HY-172314 関連分類
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