ACLY-IN-1
ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC50 = 8.3 nM) and high binding affinity (KD = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2897695-26-8
- 分子式: C20H12BrClF2N2O4S
- 分子量:529.74
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
ACLY-IN-1 is very stable in human microsomes with long half-life (T1/2 > 120 min) and low intrinsic microsome clearance (Clint = 6.7 mL/min/kg)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ACLY-IN-1 (1 g/kg, p.o.) has no death of C57BL/6JNifdc mice and no obvious toxic effects within 1 week after the treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male LDL-R-/- mice (7-8 weeks)[1]
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Dosage:30 mg/kg
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Administration:p.o., 30 mg/kg, once daily for 8 weeks.
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Result:Reduced serum triglyceride.
Reduced total cholesterol and LDL-c levels.
Reduced the liver weight and liver/body weight ratio.
Reversed the elevated hepatic triglyceride and total cholesterol in in LDL-R-/- mice.
化学情報
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CAS 番号 2897695-26-8
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分子量 529.74
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分子式 C20H12BrClF2N2O4S
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SMILES
ClC1=CC2=CC(S(=O)(NC3=CC(C4=C(C=CC(Br)=C4)CNC2=O)=C(C=C3F)F)=O)=C1O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ACLY-IN-1 関連分類
HY-172914 関連分類
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