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製品番号: HY-187838S

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Adonertinib

Name: Adonertinib
Brand: MedChemExpress
SKU: HY-187838S
Availability: PreOrder

(別名: FHND9041)

Adonertinib (FHND9041) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which is applicable to research related to advanced non-small cell lung cancer carrying EGFR-sensitive mutations.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2211116-92-4
分子式: C₃₀H₃₂D₃N₇O₂
分子量:528.66

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Adonertinib 構造式

CAS 番号: 2211116-92-4

容量

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性
- 製品説明
- 体外実験
- 体内実験
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

EGFR アイソフォーム固有の製品をすべて表示 :

体外実験

Adonertinib (FHND9041) covalently binds to mutant EGFR and exhibits low inhibitory activity against wild-type EGFR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Adonertinib (FHND9041) exhibits superior progression-free survival benefits and a lower incidence of adverse events in advanced NSCLC harboring sensitive EGFR mutations, particularly the EGFR Ex19del mutation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

アプリケーション

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

化学情報

CAS 番号 2211116-92-4
非標識Cas 1825287-91-9
分子量 528.66
分子式 C₃₀H₃₂D₃N₇O₂
SMILES

COC(C=C(C(NC(C=C)=O)=C1)N(C)CCN(C)C([2H])([2H])[2H])=C1NC2=NC=CC(C(C3=CC=C4)=CN5C3=C4CCC5)=N2
別名

FHND9041
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Shi Y K, et al. Adonertinib (FHND9041) versus Afatinib as First‑line Treatment for Advanced Non‑small‑cell Lung Cancer with EGFR Sensitive Mutation (FHND9041‑III‑01): A Multi‑centre, Open‑label, Randomised Phase 3 Trial. 2026.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Minimum order quantity

100 mg

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