AGS-16C3F
Based on 1 Customer Validation
AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3. AGS-16C3F is composed of ENPP3-targeting Anti-ENPP3/CD203c Antibody (HY-P990315) linked to Monomethyl auristatin F (HY-15579) via a linker. AGS-16C3F has anti-tumor activity and can be used in the study of metastatic renal cell carcinoma (mRCC).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.81%
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保管条件:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PDE3 |
AGS-16C3F (0.001-1350 nM, 96 h) has IC50 of 1.1 nM, 2.73 nM, 109.9 nM and 146.5 nM in ROSA KIT D816V, ROSA KIT D816V-Gluc, HMC-1.1 and HMC-1.2 cells, respectively, shows potent inhibitory activity against the proliferation of ROSA cells with high expression of CD203c[2].
AGS-16C3F (0.5-100 nM, 96-120 h) induces apoptosis and kills tumor cells with high expression of CD203c in ROSA KIT D816V, ROSA KIT D816V-Gluc, HMC-1.1 and HMC-1.2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ROSA KIT D816V, ROSA KIT D816V-Gluc, HMC-1.1 and HMC-1.2 cells
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Concentration:0.5-100 nM
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Incubation Time:96-120 h
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Result:Significantly increased the proportion of apoptotic cells in ROSA cells (dose-dependent).
Had a low apoptosis rate in HMC-1 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD-SCID γ mice injected with ROSA KIT D816V-Gluc (5 million cells)[2]
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Dosage:1,4 mg/kg
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Administration:i.v. once every 4 days, 4 times in total
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Result:Significantly reduced the number of tumor cells in peripheral blood, bone marrow, and spleen, and decreased serum tryptase levels.
During treatment and after drug withdrawal, the luciferase activity (marker of tumor burden) of mice in the high-dose group continued to be lower than that in the control group, and disease recurrence was delayed.
Significantly prolonged the survival of mice.
Showed a significant increase in apoptotic cells in the mouse bone marrow, indicating that the anti-tumor effect was mainly achieved by inducing apoptosis.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[AGS-16C3F]
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別名
AGS-16M8F
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輸送条件
Shipping with dry ice.
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保管条件
-80°C, protect from light
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kollmannsberger C, et al. A Randomized Phase II Study of AGS-16C3F Versus Axitinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma. Oncologist. 2021 Mar;26(3):182-e361. [Content Brief]
[2]. Zhang Y, et al. In vitro and in vivo efficacy of an anti-CD203c conjugated antibody (AGS-16C3F) in mouse models of advanced systemic mastocytosis. Blood Adv. 2019 Feb 26;3(4):633-643. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AGS-16C3F 関連分類
HY-171544 関連分類
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