AKI-001
AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 925218-37-7
- 分子式: C21H24N4O
- 分子量:348.44
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Aurora Kinase アイソフォーム固有の製品をすべて表示
More
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.07 μM
Compound: 32, AKI-001
|
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
|
[PMID: 18630890] |
| HT-29 | IC50 |
0.07 μM
Compound: 32, AKI-001
|
Antiproliferative activity against human HT29 cells
Antiproliferative activity against human HT29 cells
|
[PMID: 18630890] |
| MCF7 | IC50 |
0.1 μM
Compound: 32, AKI-001
|
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
|
[PMID: 18630890] |
| MOLT-4 | IC50 |
0.11 μM
Compound: 32, AKI-001
|
Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs
Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs
|
[PMID: 18630890] |
化学情報
-
CAS 番号 925218-37-7
-
分子量 348.44
-
分子式 C21H24N4O
-
SMILES
O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AKI-001 関連分類
HY-119951 関連分類
Powered by Bioz