Albaconazole
Albaconazole (UR 9825) is a broad-spectrum triazole and oral activity antifungal agent.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 187949-02-6
- 分子式: C20H16ClF2N5O2
- 分子量:431.82
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
34.86 μM
Compound: 7
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Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay
Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay
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[PMID: 24564525] |
Albaconazole (UR 9825) shows antifungal activity with MIC50s of ≤0.0002, ≤0.0002, ≤0.0002, 0.06, 0.015, ≤0.0002 mg/L for C. albicans, C. parapsilosis,C. tropicalis, C. glabrata, C. krusei, C. guilliermondii, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:2.5 kg New Zealand White male rabbits[2]
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Dosage:15, 25, 50 mg/kg
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Administration:P.o.; once daily for 10 days
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Result:Showed lower tissue burdens than the control group.S. prolificans was undetectable in the liver, spleen, and lung cultures, attenuated the histopathological severity in the kidney.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 187949-02-6
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分子量 431.82
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分子式 C20H16ClF2N5O2
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SMILES
C[C@@H](N1C(C2=CC=C(Cl)C=C2N=C1)=O)[C@@](O)(C3=C(C=C(C=C3)F)F)CN4C=NC=N4
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別名
UR 9825
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ramos G, et al. In-vitro comparative activity of UR-9825, itraconazole and fluconazole against clinical isolates of Candida spp. J Antimicrob Chemother. 1999 Aug;44(2):283-6. [Content Brief]
[2]. Capilla J, et al. Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits. Antimicrob Agents Chemother. 2003 Jun;47(6):1948-51. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Albaconazole 関連分類
HY-106141 関連分類
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