Alexidine
Based on 5 publication(s) in Google Scholar
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 22573-93-9
- 分子式: C26H56N10
- 分子量:508.79
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Alexidine (10 µM, 24 hours) treatment can decimate the biofilm community[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:C. albicans, C. auris, A. fumigatus
-
Concentration:10 µM
-
Incubation Time:24 hours
-
Result:Could significantly kill 80% of mature biofilm community.
-
Cell Line:HUVECs, lung A549 cells
-
Concentration:0-60 μg/ml
-
Incubation Time:24 hours
-
Result:resulted in 50% killing of HUVECs and lung A549 cells ( CC50 > 7.37 μg/ml ).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:8-week-old C57BL/6 male mice
-
Dosage:3 µg/ml
-
Administration:Jugular vein-catheterized, 48 hours, 3 µg/ml, once
-
Result:Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
化学情報
-
CAS 番号 22573-93-9
-
分子量 508.79
-
分子式 C26H56N10
-
SMILES
N=C(NCC(CC)CCCC)NC(NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N)=N
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Cell Death Dis
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis. [Abstract]2025 Apr 6;16(1):257. PMID: 40189563 -
Free Radic Biol Med
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation. [Abstract]2025 Jun 14:237:585-599. PMID: 40518125 -
Cell Rep
A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]2025 Nov 25;44(11):116496. PMID: 41166305 -
Biochem Biophys Res Commun
2026 Jan 18:796:153158. PMID: 41418346 -
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Alexidine 関連分類
HY-B1474 関連分類
Powered by Bioz