country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-12941

Copy Link Print Information

AM-7209

AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a K_d of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC₅₀ of 1.6 nM. AM-7209 shows antitumor activities.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1623432-51-8
分子式: C₃₇H₄₁Cl₂FN₂O₇S
分子量:747.70

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

AM-7209 構造式

CAS 番号: 1623432-51-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	ED₅₀	10 mg/kg Compound: 25, AM-7209	Antitumor activity against human HCT116 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd starting on day 10 of tumor implantation Antitumor activity against human HCT116 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd starting on day 10 of tumor implantation	[PMID: 25384157]
HCT-116	IC₅₀	>25 μM Compound: 25, AM-7209	Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay	[PMID: 25384157]
HCT-116	IC₅₀	2 nM Compound: 25, AM-7209	Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay	[PMID: 25384157]
SJSA-1	ED₅₀	2.6 mg/kg Compound: 25, AM-7209	Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days	[PMID: 25384157]

化学情報

CAS 番号 1623432-51-8
分子量 747.70
分子式 C₃₇H₄₁Cl₂FN₂O₇S
SMILES

O=C(O)C1=CC=C(NC(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)=O)C=C1OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yosup Rew, et al. Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem. 2014 Dec 26;57(24):10499-511. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ