AM12814
AM12814 is a potent and partial CB1 and CB2 agonist with Ki values of 0.7 nM and 3.4 nM. AM12814 can inhibit cAMP accumulation and recruitse β-arrestin 2. AM12814 exhibits cannabimimetic effects. AM12814 can be used for the research of neurological disease, suah as catalepsy.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3054511-18-8
- 分子式: C24H38F3NO2
- 分子量:429.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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rCB1-R 0.7 nM (Ki) |
hCB2-R 3.4 nM (Ki) |
AM12814 (Compound 12) binds to cannabinoid receptors with high affinity, with Ki values of 0.7 nM (rCB1) and 3.4 nM (hCB2)[1].
AM12814 (30 mins) inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in 3xHA-hCB1-CHO and 3xHA-hCB2-CHO cells with EC50 values of 8.75 nM and 22 nM[1].
AM12814 (90 mins) recruitses β-arrestin 2 in hCB1-DRx-CHO and hCB2-DRx-U2OS cells with EC50 values of 25 nM and 5.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice[1]
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Dosage:0.3, 1 and 3 mg/kg
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Administration:Intraperitoneally injection
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Result:Increased immobility time in the ring test.
Reduced core body temperature.
Prolonged tail-flick latency in the hot water test.
Alleviated CFA (HY-153808)-induced mechanical hypersensitivity.
化学情報
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CAS 番号 3054511-18-8
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分子量 429.56
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分子式 C24H38F3NO2
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SMILES
O=C(N[C@H](C)CO)CCC/C=C\C/C=C\C/C=C\[C@@H](C)/C=C\CCCCC(F)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AM12814 関連分類
HY-178203 関連分類
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