AN13762
AN13762 is a benzoxaborole antimalarial agent. AN13762 augments Plasmodium falciparum stress responses. AN13762 acts against cultured and fresh Plasmodium falciparum isolates and in vivo murine malaria models. AN13762 can be used for the research of malaria.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2025371-99-5
- 分子式: C17H18BN3O5
- 分子量:355.15
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
AN13762 (1 nM-10 μM; 48 h) potently inhibits the growth of Plasmodium falciparum laboratory strains (3D7, W2, Dd2, 7G8, VS1, K1, D6) with IC50 values ranging from 18 nM to 118 nM[1].
AN13762 (72 h) potently inhibits the growth of fresh Plasmodium falciparum clinical isolates from Uganda[1].
AN13762 (500 nM; 8 h) exhibits the greatest antimalarial activity against ring- and trophozoite-stage Plasmodium falciparum Dd2 parasites, causing abnormal trophozoite morphology and preventing further development[1].
AN13762 produces low-level resistant Plasmodium falciparum (Dd2, 3D7, W2) with PfPARE mutations (IC50 = 180-1340 nM) and high-level resistant parasites with additional ubiquitination/sumoylation or PfCPSF3 mutations (IC50 = 1.1-5.0 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2025371-99-5
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分子量 355.15
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分子式 C17H18BN3O5
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SMILES
O=C(N1CC(C)(C1)O)C2=CN=C(OC3=CC=C4C(B(OC4)O)=C3C)C=N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AN13762 関連分類
HY-148269 関連分類
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