Anti-aging agent 2
Anti-aging agent 2 is an anti-aging agent. Anti-aging agent 2 attenuates senescence-associated secretory phenotype (SASP), alleviates cell cycle arrest, reduces the levels of senescence markers in renal tissues, and downregulates the expression of p21, p16 and p53 in the kidney. Anti-aging agent 2 improves renal function and alleviates renal fibrosis. Anti-aging agent 2 extends the lifespan of Caenorhabditis elegans. Anti-aging agent 2 can be used in the research of chronic kidney disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H24FNO3
- 分子量:417.47
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| NRK-52E | IC50 |
>100 μM
|
Cytotoxicity against rat renal NRK-52E cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
Cytotoxicity against rat renal NRK-52E cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
|
42501452 |
| MRC5 | IC50 |
>100 μM
|
Cytotoxicity against human embryonic lung fibroblast MRC-5 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
Cytotoxicity against human embryonic lung fibroblast MRC-5 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
|
42501452 |
体外実験
Anti-aging agent 2 (Compound C36) (5-100 μM; 72 h) has low cytotoxicity in NRK-52E and MRC-5 cells, with an IC50 > 100 μM after 72 h[1].
Anti-aging agent 2 (10 μM; 72 h) reduces senescence markers p21 and SA-β-gal and restores AMPK-mTOR pathway homeostasis in Mitomycin C (HY-13316)-induced senescent NRK-52E cells[1].
Anti-aging agent 2 (10 μM; 72 h) reduces senescence markers p21, p16, and γ-H2AX in replicative senescent MRC-5 cells (passage 31)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:NRK-52E rat renal cells, MRC-5 human embryonic lung fibroblasts
-
Concentration:5-100 μM
-
Incubation Time:72 h
-
Result:Exhibited low cytotoxicity, with an IC50 > 100 μM in both NRK-52E and MRC-5 cells.
Maintained cell viability near 100% of control across all tested concentrations.
-
Cell Line:Mitomycin C-induced senescent NRK-52E rat renal cells
-
Concentration:10 μM
-
Incubation Time:72 h
-
Result:Significantly downregulated the expression of senescence-associated markers p21 and SA-β-gal.
Restored mTOR protein levels and reduced the p-AMPK/AMPK ratio, reestablishing metabolic homeostasis in the AMPK-mTOR pathway.
-
Cell Line:Replicative senescent MRC-5 human embryonic lung fibroblasts (passage 31)
-
Concentration:10 μM
-
Incubation Time:72 h
-
Result:Significantly decreased the expression of senescence-associated markers p21, p16, and γ-H2AX.
体内実験
Anti-aging agent 2 (5-20 mg/kg) improves liver and kidney function, reduces SASP levels, and downregulates renal senescence markers in Doxorubicin (HY-15142A)-induced senescent mice, with the 20 mg/kg dose delivering the most prominent effect[1].
Anti-aging agent 2 (5-20 mg/kg) improves renal function, reduces SASP levels, alleviates renal fibrosis, and downregulates renal senescence markers in mice with UIRI-induced chronic kidney disease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Caenorhabditis elegans[1]
-
Dosage:64 mg/L
-
Administration:continuous exposure in culture medium
-
Result:Extended mean lifespan by 11.49% compared to control.
Significantly increased body-bending frequency on day 8 compared to control and lead compound C1.
Elevated pharyngeal pumping rates on days 8 and 11 compared to control and lead compound C1.
Improved egg-laying behavior on days 2, 3, and 4 relative to control and lead compound C1.
化学情報
-
分子量 417.47
-
分子式 C26H24FNO3
-
SMILES
COC1=CC=C(C2=NC3=CC(OC(C)C)=C(F)C=C3C(OCC4=CC=CC=C4)=C2)C=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anti-aging agent 2 関連分類
HY-187429 関連分類
Powered by Bioz