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製品番号: HY-146063

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Anticancer agent 54

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation.

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CAS 番号: 2933882-99-4
分子式: C₃₃H₃₆N₆
分子量:516.68

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 54 構造式

CAS 番号: 2933882-99-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.75 μM Compound: Table 1, R1C1	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
HCT-116	IC₅₀	0.27 μM Compound: Table 1, R1C1	Antiproliferative activity against human HCT 116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human HCT 116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	0.039 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CuSO4 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CuSO4 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	0.04 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CdSO4 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CdSO4 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeCl3 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeCl3 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeSO4 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeSO4 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of ZnCl2 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of ZnCl2 by MTS assay	[PMID: 31962262]
NHDF	IC₅₀	20.83 μM Compound: Table 1, R1C1	Cytotoxicity against human NHDF cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Cytotoxicity against human NHDF cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
PANC-1	IC₅₀	0.44 μM Compound: Table 1, R1C1	Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
U-251	IC₅₀	0.14 μM Compound: Table 1, R1C1	Antiproliferative activity against human U251 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human U251 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]

体外実験

Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC₅₀s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively^[1].
Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner^[1].
Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 2.5, 5 µM
Incubation Time:

24 h
Result:

Induced cell cycle arrest at G0/G1 phases in a concentration-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 2.5, 5 µM
Incubation Time:

24 h
Result:

The level of the apoptotic cells increased from 7.62% to 29.33% and the population of living cells decreased from 92.01% to 55.27% at 5 µM.

Related Protocols :

化学情報

CAS 番号 2933882-99-4
分子量 516.68
分子式 C₃₃H₃₆N₆
SMILES

CCCCCCCCCCN1C=C(N=N1)C2=CC=C(C=C2)C3=CC(C4=NC=CC=C4)=NC(C5=CC=CC=N5)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Malarz K,et al.Anticancer activity of 4'-phenyl-2,2':6',2″-terpyridines - behind the metal complexation. Eur J Med Chem. 2020 Mar 1;189:112039. [Content Brief]

Calculators

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100 mg

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