Anticancer agent 89
Anticancer agent 89 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity, has high inhibition against the three cell line from ovarian cancer (OVCAR-4), renal cancer (A498), and melanoma (SK-MEL-5).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2977251-05-9
- 分子式: C32H29BrN2O10S3
- 分子量:777.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Anticancer agent 89 (compound 6f) (0.01 mM; 24 h) has low cytotoxicity, shows high inhibition against three cell lines, SK-MEL-5, OVCAR-4, and A498[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:FRHK-4, Hep2, BGM, Vero, and Huh 7.5 cell lines
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Concentration:0-200 μg/mL
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Incubation Time:24 hours
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Result:Showed nontoxic under the doses of 90 μg/mL (FRHK-4), 90 μg/mL (Hep2), μg/mL (BGM), 90 μg/mL (Vero), and 100 μg/mL (Huh 7.5), respectively.
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Cell Line:SK-MEL-5, OVCAR-4, and A498
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Concentration:0.01 mM
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Incubation Time:24 hours
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Result:Inhibited SK-MEL-5, OVCAR-4, and A498 cell viability by 36.29%, 46.89%, and 36.08%, respectively.
化学情報
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CAS 番号 2977251-05-9
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分子量 777.68
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分子式 C32H29BrN2O10S3
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SMILES
O=C(C1=C(N)C(C2=NC3=CC=CC=C3S2)=C(S[C@H]4[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@](OC(C)=O)([H])[C@@H](COC(C)=O)O4)S1)C5=CC=C(Br)C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 89 関連分類
HY-151587 関連分類
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