Anticancer agent 99
Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect.
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- CAS 番号: 2914922-83-9
- 分子式: C19H20F3N3O2
- 分子量:379.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Anticancer agent 99 (0-50 μM, 24 h) directly upregulates Bax expression and induces caspase-3-dependent apoptosis in HepG2 cell line, with antiproliferative effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cell
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Concentration:25, 50 μM
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Incubation Time:24 h
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Result:Increased mRNA transcript levels of pro-apoptotic Bax and Caspase-3 genes.
Reduced Akt protein levels in HepG2 cells.
Increased FoXO1, TXNIP and p27 protein levels in HepG2 cells.
化学情報
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CAS 番号 2914922-83-9
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分子量 379.38
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分子式 C19H20F3N3O2
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SMILES
O=C(C1=CC=C(NCCCC)C=C1)N/N=C/C2=C(OC(F)(F)F)C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 99 関連分類
HY-149061 関連分類
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