Antitrypanosomal agent 9
Based on 1 Customer Validation
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 90%
- CAS 番号: 438474-67-0
- 分子式: C22H27NO3
- 分子量:353.45
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.15 μM
Compound: 1
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Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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10.1039/C4MD00406J |
| L6 | IC50 |
107 μM
Compound: 1
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Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
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10.1039/C4MD00406J |
| L6 | IC50 |
186 μM
Compound: 1
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Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
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10.1039/C4MD00406J |
Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1].
Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 438474-67-0
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性状 Powder
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分子量 353.45
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分子式 C22H27NO3
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Color Light brown to brown
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SMILES
N1(CCCC(C)C1)C(=O)C1C=CC(COC2C=CC(OCC)=CC=2)=CC=1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (267 KB)
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SDS (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitrypanosomal agent 9 関連分類
HY-Q40175 関連分類
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