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製品番号: HY-147884

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Antitubercular agent-28

Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC₅₀ value of 1.5 µM, an MIC value of 4.5 µM, an IC₉₀ value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity.

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CAS 番号: 2460651-10-7
分子式: C₁₇H₁₄N₄O₂
分子量:306.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitubercular agent-28 構造式

CAS 番号: 2460651-10-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Antitubercular agent-28 (compound 2) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC₅₀s of 2.9, 125, 130, 1.3, 3.8 µM, MICs of 3.3, 170, 190, 1.8, 8.4 µM, IC₉₀s of 3.1, 140, 180, 1.5, 4.8 µM for FQ-R1, INH-R1, INH-R2, RIF-R1,RIF-R2 respectively^[1].
Antitubercular agent-28 (0-200 µM) shows antibacterial activity with an MIC value of 170 µM, IC₅₀ value of 2.96 µM, and IC₉₀ value of 19 µM in low oxygen condition, and an MIC value of 1.77 µM, IC₅₀ value of 1.02 µM, and IC₉₀ value of 1.34 µM in normal oxygen condition^[1].
Antitubercular agent-28 (0-200 µM) shows intracellular activity with an IC₅₀ value of 2.15 µM, and IC₉₀ value of 2.85 µM, and low cytotoxicity with an IC₅₀ value of >100 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2460651-10-7
分子量 306.32
分子式 C₁₇H₁₄N₄O₂
SMILES

O=C(NN1C(C2CC2)=NC3=C(C=CC=C3)C1=O)C4=CC=NC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Patel H, et al. Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis. Bioorg Chem. 2020 Sep;102:104099. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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