Antituberculosis agent-10
Antituberculosis agent-10 (Compound 9) has excellent antibacterial activity against Mycobacterium tuberculosis (MIC = 0.3 μM). Antituberculosis agent-10 inhibits protein synthesis by targeting the 50S ribosomal subunit of the bacterium, thus exerting its antibacterial effect. Antituberculosis agent-10 is orally active.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2095636-19-2
- 分子式: C17H17FN2O4S
- 分子量:364.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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- 純度とドキュメンテーション
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Help & FAQs
生物活性
製品説明
体外実験
Antituberculosis agent-10 (72 h) is inactive in inhibiting mitochondrial protein synthesis (MPS) in HepG2 cells (IC50 = 150 μM), but its metabolites shows mitochondrial toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Antituberculosis agent-10 ((i.g.; 4 mg/kg; twice daily for one week then once daily ) reduces the volume of tuberculosis foci in Mtb-infected marmosets with potent antibacterial activity[1].
Pharmacokinetic Analysis in Antituberculosis agent-10[1]
| Route | Dose (mpk) | Cl/Clu (mL/min/kg) | Vd/Vdu (L/kg) | MRT/ss t1/2 (h) | F (%) |
| i.v. | 2 | 12/316 | 0.6/16 | 0.8/0.6 | / |
| p.o. | 10 | / | / | / | 64 |