Antituberculosis agent-9
Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra.
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- CAS 番号: 2998587-72-5
- 分子式: C25H29ClN4O
- 分子量:436.98
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
3.1 μM
Compound: 5a
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 36735271] |
Antituberculosis agent-9 (Compound 5a; 48 h) shows cytotoxicity against HepG2 cells with an IC50 value of 3.1 μM[1].
Antituberculosis agent-9 (6 days) also shows inhibitory activities against MRSA, M. abscessus and M. smegmatis with MICs of 4.0 μg/mL[1].
Antituberculosis agent-9 (6 days) shows inhibitory activities against clinical isolates of M. tuberculosis with MICs of 0.5, 0.5, 0.5, 1.0 and 1.0 μg/mL for H37Rv, K4, K12, K5 and K16, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice, autoluminescent Mtb infection model[1]
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Dosage:300 mg/kg
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Administration:Oral administration, daily for 4 days
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Result:There was a relative light unit (RLU) reduction of 0.5 log10 in live mice, compared to the control group (CMC-Na).
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Animal Model:Sprague-Dawley rats[1]
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Dosage:5 or 15 mg/kg
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Administration:IV or PO (Pharmacokinetic Analysis)
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Result:Pharmacokinetic Parameters of Antituberculosis agent-9 (Compound 5a) In Vivo[1]
cpd. administration Cmax (μg/L) Tmax (h) T1/2 (h) Clz (L/h/kg) AUC0-t (μg/L•h) F % Antituberculosis agent-9 (Compound 5a) iv (5 mg/kg) 595 ± 62 26.2 ± 0.9 1.5 ± 0.3 1694 ± 201 po (15 mg/kg) 108 ± 18 >24 2079 ± 274 40.7
化学情報
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CAS 番号 2998587-72-5
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分子量 436.98
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分子式 C25H29ClN4O
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SMILES
CC1=C(C2CCNCC2)C=C(OC(C)C)C(NC3=C(Cl)C=NC(C4=CC=CC=C4)=N3)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antituberculosis agent-9 関連分類
HY-149064 関連分類
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