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製品番号: HY-114602

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AR-C117977

AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 216685-07-3
分子式: C₂₅H₂₈N₂O₃S₂
分子量:468.63

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AR-C117977 構造式

CAS 番号: 216685-07-3

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Monocarboxylate Transporter アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against HEK293 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against HEK293 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
HT-29	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
HUVEC	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HUVEC assessed as inhibition of basic FGF-stimulated cell proliferation by fluorimetric assay Antiproliferative activity against human HUVEC assessed as inhibition of basic FGF-stimulated cell proliferation by fluorimetric assay	[PMID: 16370372]
HUVEC	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HUVEC assessed as inhibition of acidic FGF-stimulated cell proliferation by fluorimetric assay Antiproliferative activity against human HUVEC assessed as inhibition of acidic FGF-stimulated cell proliferation by fluorimetric assay	[PMID: 16370372]
K562	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
Keratinocyte	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human primary epidermal keratinocytes assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human primary epidermal keratinocytes assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
PANC-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
SW480	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
T-24	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human T24 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human T24 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
THP-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human THP1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human THP1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
ZR-75-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]

化学情報

CAS 番号 216685-07-3
分子量 468.63
分子式 C₂₅H₂₈N₂O₃S₂
SMILES

O=C1N(CC(C)C)C2=C(C(SCCCO)=C(CC3=C4C=CC=CC4=CC=C3)S2)C(N1C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bueno V, et al. The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. Transplantation. 2007 Nov 15;84(9):1204-7. [Content Brief]

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モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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AR-C117977

Monocarboxylate Transporter アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

AR-C117977 関連分類

HY-114602 関連分類