(Arg)9 TFA
Based on 1 publication(s) in Google Scholar
(Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.57%
- CAS 番号: 2283335-13-5
- 分子式: C54H110N36O10.xC2HF3O2
- 分子量:1423.69 (free acid)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 (Arg)9 TFA
More
生物活性
製品説明
IC50 & Target
IC50: 0.78 μM (neuroprotection)[1].
体外実験
(Arg)9 (Nona-L-arginine; 5-10 μM) TFA provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 TFA is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 TFA also shows neuroprotection following in vitro ischemia (IC50=6 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague–Dawley rats (270 to 320 g) permanent middle cerebral artery stroke model[2]
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Dosage:1 μM/kg (600 μL)
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Administration:Intravenous injection; once, over 5 minutes
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Result:Reduced significantiy 20% in infarct volume.
化学情報
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CAS 番号 2283335-13-5
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性状 Solid
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分子量 1423.69 (free acid)
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分子式 C54H110N36O10.xC2HF3O2
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Color White to off-white
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別名
Nona-L-arginine TFA; Peptide R9 TFA
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配列
Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
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シーケンスの短縮
RRRRRRRRR
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
純度とドキュメンテーション
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データシート (270 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81. [Content Brief]
[2]. Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(Arg)9 TFA 関連分類
HY-P0133A 関連分類
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