As-358
As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2222042-47-7
- 分子式: C18H31NO2
- 分子量:293.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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EBOV |
MARV |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
302 μM
Compound: 4
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 30108738] |
| HEK-293T | CC50 |
289.7 μM
Compound: 3b; As-358
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Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
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[PMID: 32905862] |
| MDCK | CC50 |
69.6 μM
Compound: 14
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Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
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[PMID: 30108810] |
| Vero | CC50 |
442.9 μM
Compound: 3b; As-358
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
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[PMID: 32905862] |
体外実験
As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV[1].
As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC50s of 1.7 and 2.2 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:Vero (infected with EBOV and MARV)[1]
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Concentration:0-500 μM
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Incubation Time:10 days
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Result:Exhibited inhibitory activities against EBOV and MARV, with IC50s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively.
化学情報
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CAS 番号 2222042-47-7
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分子量 293.44
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分子式 C18H31NO2
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SMILES
O=C(O[C@@H]1C[C@@H]2CC[C@]1(C2(C)C)C)CCN3CCCCC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
As-358 関連分類
HY-146883 関連分類
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