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製品番号: HY-183406

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AS15

AS15 is a PDIA1 inhibitor with an IC₅₀ value of 300 nM. AS15 interacts with the active-site cysteine of PDIA1, and this process is independent of the substrate-binding domain of PDIA1. AS15 acts as a synergistic cell growth inhibitor with buthionine sulfoximine (BSO) (HY-106376), a glutathione synthesis inhibitor. AS15 can be used in the research of glioblastoma.

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CAS 番号: 102616-62-6
分子式: C₂₀H₂₃NO₆
分子量:373.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AS15 構造式

CAS 番号: 102616-62-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

PDIA1

300 nM (IC₅₀)

体外実験

AS15 reduces the viability of U-87 MG glioblastoma cells, with an IC₅₀ of 18.3 μM^[1].
AS15 (0.3-3 μM; 24 h) reduces the colony-forming ability of U-118 MG glioblastoma cells, and its activity can be enhanced by glutathione depletion via pre-treatment with BSO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

U-118 MG glioblastoma cells
Concentration:

0.3, 1 and 3 μM
Incubation Time:

24 h (BSO pretreatment)
Result:

Increased potency in reducing colony formation after pretreatment with BSO (a glutathione synthesis inhibitor), supporting that glutathione depletion sensitizes glioblastoma cells to AS15.

化学情報

CAS 番号 102616-62-6
分子量 373.40
分子式 C₂₀H₂₃NO₆
SMILES

OC1=C(C(N2CCOCC2)C3=CC=C(C(OC)=C3)OC)C=C4OCOC4=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Shergalis A, et al. Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines. Journal of medicinal chemistry. 2020 Sep 24;63(18):10263-10286. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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