AT1412
AT1412 is a CD9-binding antibody. AT1412 binds to the tetraspanin protein CD9 and modulates CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration. AT1412 binds to B-ALL cell lines but not to T-ALL. AT1412 induces antibody-dependent cellular cytotoxicity in B-ALL cell lines. AT1412 binds to melanoma cells, B-ALL, gastric cancer, colorectal cancer, and pancreatic cancer cells [1] .
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Species Reactivity
Human
IC50 & Target
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CD9 |
体外実験
AT1412 binds thetetraspanin CD9, can regulate CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration [2].
AT1412 induces antibody-dependent cytotoxicity in B-ALL cell lines SUP-B15, MHH-CALL-2 and CCRF-SB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
アプリケーション
ELISA, FACS, Functional assay
化学情報
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別名
AT14-012
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AT1412 関連分類
HY-P991896 関連分類
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Keywords
- AT1412
- AT14-012
- AT 1412
- AT-1412
- Transmembrane Glycoprotein
- B-ALL blasts
- antibody dependent cellular cytotoxicity
- A375-CD9KO
- CD8 T-cell
- ICAM-1
- A375 melanoma
- A375wt
- ADCP
- B-ALL
- effector cells
- melanoma cells
- LFA-1
- CD9
- human immune system mouse models
- granulocytic
- VLA-4
- lymphocytic populations
- metastatic melanoma
- T cells
- tetraspanin CD9
- endothelial cells
- colon cancer cells
- ADCC
- monocytic
- HIS mouse models
- nivolumab
- SK-MEL5 melanoma cells
- PD-1 resistant SK-MEL5 melanoma model
- pancreatic cancer cells
- gastric cancer cells
- HUVEC cells
- antibody-dependent cellular phagocytosis
- NSG mice
- cd9 positive precursor b-acute lymphoblastic leukemia
- macrophage
- integrin signaling
- VCAM-1
- Inhibitor
- inhibitor
- inhibit