Auriculin A
Auriculin A is a synthetic atrial natriuretic factor (ANF) with hemodynamic effect. Auriculin A antagonizes renal vasoconstriction in the dog, and influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 91421-87-3
- 分子式: C104H168N38O33S2
- 分子量:2542.81
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
Auriculin A (2 μg/kg prime, 0.2 μg/kg/min; i.v.; for 45 min) influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female mongrel dogs used in early clamp experiments (15-20 kg, anesthetized with 30 mg/kg pentobarbital sodium i.v.)[1]
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Dosage:0.3 μg/min/kg
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Administration:Intravenous injection; last for 30 min
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Result:Increased glomerular filtration rate (GFR) 16±4% and Na excretion (UNa V) 261±63%, whereas it decreased urine osmolality (Uosm) 36±7% without changing free water clearance.
Also increased diuresis (V) and kaliuresis (UKV).
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Animal Model:New Zealand white male rabbits (3-3.5 kg, anesthetized with 50 mg/kg Chloralose (HY-B1020) and 500 mg/kg Urethane (HY-B1207) i.v.)[2]
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Dosage:0.5 μg/kg prime, 0.05 μg/kg/min; 2 μg/kg prime, 0.2 μg/kg/min; 4 μg/kg prime, 0.4 μg/kg/min; 8 μg/kg prime, 0.8 μg/kg/min
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Administration:Intravenous injection; last for 30-60 min
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Result:Significantly reduced mean blood pressure and increased mean perfusion pressure at 4 μg/kg prime, 0.4 μg/kg/min dose, while heart rate did not change.
化学情報
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CAS 番号 91421-87-3
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分子量 2542.81
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分子式 C104H168N38O33S2
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シーケンスの短縮
RSSCFGGRIDRIGAQSGLGCNSFR (Disulfide bridge:Cys4-Cys20)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Sosa RE, et al. Relationship between renal hemodynamic and natriuretic effects of atrial natriuretic factor. Am J Physiol. 1986 Mar;250(3 Pt 2):F520-4. [Content Brief]
[2]. Volpe M, et al. Vagal mediation of the effects of atrial natriuretic factor on blood pressure and arterial baroreflexes in the rabbit. Circ Res. 1987 May;60(5):747-55. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Auriculin A 関連分類
HY-P3765 関連分類
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