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United States

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製品番号: HY-133906

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AX13057

AX13057 is a KIAA1363 inhibitor with an IC₅₀ of 130 nM. AX13057 exhibits tumor penetration and is orally active. AX13057 can be used for research on ovarian cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1397274-79-1
分子式: C₁₆H₁₈BrNO₂
分子量:336.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AX13057 構造式

CAS 番号: 1397274-79-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

AX13057 is a KIAA1363 inhibitor with an IC₅₀ of 130 nM. AX13057 exhibits tumor penetration and is orally active. AX13057 can be used for research on ovarian cancer^[1].

IC₅₀ & Target

^[1]

KIAA1363

130 nM (IC₅₀)

体内実験

Anti-cancer

AX13057 (100 mg/kg; p.o. and i.p.) inhibits intratumoral KIAA1363 in SK-OV-3 xenograft-bearing female SCID mice, producing greater inhibition after i.p. dosing than after p.o. dosing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID (female)^[1]
Dosage:

100 mg/kg (p.o.); 100 mg/kg (i.p.)
Administration:

p.o.; i.p.
Result:

Inhibited tumor KIAA1363 by 22% after p.o. dosing with AX13057 at 100 mg/kg.
Inhibited intratumoral human KIAA1363 by 64% and mouse heart KIAA1363 by 66% after i.p. dosing with AX13057 at 100 mg/kg.

化学情報

CAS 番号 1397274-79-1
分子量 336.23
分子式 C₁₆H₁₈BrNO₂
SMILES

O=C(OC=1C=CC2=CC(=CC=C2C1Br)CCC)N(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Shreder KR, et al. Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1). Bioorganic & medicinal chemistry letters. 2012 Sep 01;22(17):5748-51. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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