Bamadutide
Based on 1 Customer Validation
Bamadutide (SAR425899) is a potent dual glucagon-like peptide-1 receptor/glucagon receptor (GLP-1R/GCGR) agonist. Bamadutide improves post-meal blood glucose control by significantly enhancing β-cell function and slowing down the rate of glucose absorption in the body. Bamadutide can be used for the research of metabolic diseases such as type 2 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 1596343-09-7
- 分子式: C200H313N51O63
- 分子量:4439.93
-
保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-P4146
Survodutide -
HY-P3375
Mazdutide -
HY-114118
Semaglutide -
HY-124177
C14 Ceramide -
HY-W717504
Glucosylceramide, plant -
HY-165035
Glucosylceramide (gaucher's spleen) -
HY-N0229S12
L-Alanine-d3 -
HY-135115
Oleuropein Aglycone -
HY-P10032A
NN1177 TFA -
HY-13580S
Budesonide-d8 -
HY-N10225
Thielavin A -
HY-B1804S
Tricaprilin-13C3
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Db/db diabetic mice[3]
-
Dosage:120 μg/kg
-
Administration:Subcutaneous injection; 6 weeks
-
Result:Reduced blood glucose levels in db/db mice.
Showed improvement in glucose tolerance and insulin resistance.
Exhibited effects in inhibiting glomerular mesangial matrix proliferation, collagen deposition, and renal fibrosis markers.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 1596343-09-7
-
性状 Solid
-
分子量 4439.93
-
分子式 C200H313N51O63
-
Color White to off-white
-
別名
SAR425899
-
配列
His-(d-Ser)-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-{N6-(N-(1-oxohexadecyl)-Ggu)-Lys}-Glu-Ser-Lys-Ala-Ala-Gln-Asp-Phe-Ile-Glu-Trp-Leu-Lys-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
-
シーケンスの短縮
H-{d-Ser}-QGTFTSDLSKQ-{N6-(N-(1-oxohexadecyl)-Ggu)-Lys}-ESKAAQDFIEWLKAGGPSSGAPPPS-NH2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
H2O : 100 mg/mL (22.52 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (294 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Olof Eriksson, et al.Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes.J Nucl Med.2021 Jun 1;62(6):833-838. [Content Brief]
[2]. Visentin R, et al. Dual glucagon-like peptide-1 receptor/glucagon receptor agonist SAR425899 improves beta-cell function in type 2 diabetes. Diabetes Obes Metab. 2020 Apr;22(4):640-647. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2252 mL | 1.1261 mL | 2.2523 mL | 5.6307 mL |
| 5 mM | 0.0450 mL | 0.2252 mL | 0.4505 mL | 1.1261 mL | |
| 10 mM | 0.0225 mL | 0.1126 mL | 0.2252 mL | 0.5631 mL | |
| 15 mM | 0.0150 mL | 0.0751 mL | 0.1502 mL | 0.3754 mL | |
| 20 mM | 0.0113 mL | 0.0563 mL | 0.1126 mL | 0.2815 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Bamadutide 関連分類
HY-P10018 関連分類
Powered by Bioz