BC-23
Based on 1 Customer Validation
BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.37%
- CAS 番号: 6298-15-3
- 分子式: C21H14ClN3O4S
- 分子量:439.87
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Ubiquitination Compound Library
HY-L050
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Anti-Blood Cancer Compound Library
HY-L079
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Protease Inhibitor Library
HY-L147
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.19 μM
Compound: PI-083
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Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
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[PMID: 22437113] |
| DU-145 | IC50 |
10.82 μM
Compound: PI-083
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Antiproliferative activity against human DU145 cells
Antiproliferative activity against human DU145 cells
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[PMID: 22437113] |
| KB | IC50 |
9.57 μM
Compound: PI-083
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Antiproliferative activity against human KB cells
Antiproliferative activity against human KB cells
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[PMID: 22437113] |
| MCF7 | IC50 |
1.96 μM
Compound: PI-083
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Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs MTT assay
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[PMID: 33039723] |
| MCF7 | IC50 |
6 μM
Compound: PI-083, NSC-45382
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Inhibition of 26S proteasome-mediated chymotrypsin like proteolytic activity in human MCF7 cells
Inhibition of 26S proteasome-mediated chymotrypsin like proteolytic activity in human MCF7 cells
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[PMID: 20621484] |
化学情報
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CAS 番号 6298-15-3
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性状 Solid
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分子量 439.87
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分子式 C21H14ClN3O4S
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Color Orange to red
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SMILES
O=S(C1=CC=C(C=C1)NC(C2=O)=C(C(C3=C2C=CC=C3)=O)Cl)(NC4=NC=CC=C4)=O
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別名
NSC 45382
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (56.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. [Content Brief]
[2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2734 mL | 11.3670 mL | 22.7340 mL | 56.8350 mL |
| 5 mM | 0.4547 mL | 2.2734 mL | 4.5468 mL | 11.3670 mL | |
| 10 mM | 0.2273 mL | 1.1367 mL | 2.2734 mL | 5.6835 mL | |
| 15 mM | 0.1516 mL | 0.7578 mL | 1.5156 mL | 3.7890 mL | |
| 20 mM | 0.1137 mL | 0.5683 mL | 1.1367 mL | 2.8417 mL | |
| 25 mM | 0.0909 mL | 0.4547 mL | 0.9094 mL | 2.2734 mL | |
| 30 mM | 0.0758 mL | 0.3789 mL | 0.7578 mL | 1.8945 mL | |
| 40 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4209 mL | |
| 50 mM | 0.0455 mL | 0.2273 mL | 0.4547 mL | 1.1367 mL |
BC-23 関連分類
HY-119288 関連分類
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