BChE-IN-4
BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2304818-41-3
- 分子式: C24H37N3O
- 分子量:383.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BChE[1]
BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)[1]
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Dosage:10, 20, 30 mg/kg
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Administration:I.p.
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Result:Significantly prolonged the step-through latencies in memory impaired mice.
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Animal Model:18-22 g, C57BL/6J mice[1]
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Dosage:30 mg/kg
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Administration:I.p.
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Result:Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task.
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Animal Model:Mice[1]
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Dosage:30 mg/kg (suspended in 1% Tween 80)
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Administration:I.p
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Result:Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test.
化学情報
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CAS 番号 2304818-41-3
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分子量 383.57
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分子式 C24H37N3O
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SMILES
O=C(NCCC1CCCCCC1)[C@@H](NCCCC)CC2=CNC3=CC=CC=C23
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BChE-IN-4 関連分類
HY-143464 関連分類
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