BDM31343
BDM31343 is an Ethionamide (HY-B0276) synergist. BDM31343 inhibits the transcriptional repressor EthR in Mycobacterium tuberculosis, thereby relieving the inhibition of the EthA activator by Ethionamide, and enhancing the efficacy of Ethionamide. BDM31343 effectively inhibits the binding of EthR to DNA, with its IC₅₀ being 3.3 μM. BDM31343 can be used in the research of anti-Mycobacterium tuberculosis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1001468-07-0
- 分子式: C14H14N4O2S
- 分子量:302.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | EC50 |
1.5 μM
Compound: 1, BDM31343
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Inhibition of EthR in Mycobacterium tuberculosis H37Rv expressing GFP infected in mouse RAW264.7 cells assessed as concentration required to ethionamide-induced 50% inhibition of bacterial growth after 5 days by microscopic analysis
Inhibition of EthR in Mycobacterium tuberculosis H37Rv expressing GFP infected in mouse RAW264.7 cells assessed as concentration required to ethionamide-induced 50% inhibition of bacterial growth after 5 days by microscopic analysis
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[PMID: 21417236] |
化学情報
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CAS 番号 1001468-07-0
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分子量 302.35
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分子式 C14H14N4O2S
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SMILES
N#CCC(N1CCC(CC1)C2=NC(C3=CC=CS3)=NO2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Willand N, et al. Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nat Med. 2009 May;15(5):537-44. [Content Brief]
[2]. Engohang-Ndong J. Antimycobacterial drugs currently in Phase II clinical trials and preclinical phase for tuberculosis treatment. Expert Opin Investig Drugs. 2012 Dec;21(12):1789-800. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BDM31343 関連分類
HY-165540 関連分類
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