BMS 695735
BMS 695735 (compound 10) is an inhibitor of IGF-1R with an IC50 value of 0.034 μM. BMS 695735 has anti-tumor activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1054315-48-8
- 分子式: C26H31ClFN7O
- 分子量:512.02
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-10191
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IGF-I (24-41)IGF-I Fragment -
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RobatumumabAnti-human IGF-1R Antibody -
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IGF-1R inhibitor-2IGF-1R Inhibitor -
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AGL-2263Insulin Receptor Inhibitor -
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Linsitinib (Standard)IGF-1R/Insulin Receptor Inhibitor -
HY-110135R
NBI-31772 (Standard)IGFBP Inhibitor
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
4 μM
Compound: 10, BMS-695735
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Inhibition of human PDE4 in U937 cells
Inhibition of human PDE4 in U937 cells
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[PMID: 18763755] |
化学情報
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CAS 番号 1054315-48-8
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分子量 512.02
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分子式 C26H31ClFN7O
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SMILES
O=C1C(C2=NC3=C(C)C=C(C4CCN(CCCF)CC4)C=C3N2)=C(NCCN5N=CC(Cl)=C5)C=CN1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity J. Med. Chem., 2008, 51 (19), pp 5897-5900 [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BMS 695735 関連分類
HY-14357 関連分類
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