BMS-P5
Based on 1 Customer Validation
BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.23%
- CAS 番号: 1549811-36-0
- 分子式: C27H33ClN6O2
- 分子量:509.04
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Epigenetics Compound Library
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Anti-Cancer Compound Library
HY-L025
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Orally Active Compound Library
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Anti-Blood Cancer Compound Library
HY-L079
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Heterocyclic Compound Library
HY-L138
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
BMS-P5 blocks calcium ionophore-induced citrullination of histone H3[1].
BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Neutrophils.
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Concentration:10 µM and 100 µM.
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Incubation Time:30 min followed by addition of DP42 or 5TGM1 CM.
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Result:Prevented MM-induced NET formation.
BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Syngeneic mouse model of MM[1].
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Dosage:50 mg/kg.
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Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.
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Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
化学情報
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CAS 番号 1549811-36-0
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性状 Solid
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分子量 509.04
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分子式 C27H33ClN6O2
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Color Off-white to light yellow
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SMILES
O=C(N1[C@@H](C)CC[C@@H](N)C1)C2=CC(OC)=C3C(N=C(C4=CC5=CC=CN=C5N4CC6CC6)N3C)=C2.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 35 mg/mL (68.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9645 mL | 9.8224 mL | 19.6448 mL | 49.1121 mL |
| 5 mM | 0.3929 mL | 1.9645 mL | 3.9290 mL | 9.8224 mL | |
| 10 mM | 0.1964 mL | 0.9822 mL | 1.9645 mL | 4.9112 mL | |
| 15 mM | 0.1310 mL | 0.6548 mL | 1.3097 mL | 3.2741 mL | |
| 20 mM | 0.0982 mL | 0.4911 mL | 0.9822 mL | 2.4556 mL | |
| 25 mM | 0.0786 mL | 0.3929 mL | 0.7858 mL | 1.9645 mL | |
| 30 mM | 0.0655 mL | 0.3274 mL | 0.6548 mL | 1.6371 mL | |
| 40 mM | 0.0491 mL | 0.2456 mL | 0.4911 mL | 1.2278 mL | |
| 50 mM | 0.0393 mL | 0.1964 mL | 0.3929 mL | 0.9822 mL | |
| 60 mM | 0.0327 mL | 0.1637 mL | 0.3274 mL | 0.8185 mL |
BMS-P5 関連分類
HY-137655 関連分類
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