BMS711939
BMS711939 is a selective agonist for peroxisome proliferator-activated receptor α (PPAR α), with EC50 of 4 nM and 4.5 μM, for human PPARα and human PPARγ. BMS711939 exhibits good pharmacokinetic characters in rats models. BMS711939 increases HDL cholesterol, reduces LDL cholesterol and triglycerides.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1000998-62-8
- 分子式: C22H20ClFN2O6
- 分子量:462.86
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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hPPARα 4 nM (IC50) |
hPPARγ 4.5 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
4 nM
Compound: 3; BMS-711939
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Agonist activity at Gal4-tagged human PPAR-alpha expressed in HEK cells by transactivation assay
Agonist activity at Gal4-tagged human PPAR-alpha expressed in HEK cells by transactivation assay
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[PMID: 27326332] |
| HEK293 | EC50 |
4511 nM
Compound: 3; BMS-711939
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Agonist activity at Gal4-tagged human PPAR-gamma expressed in HEK cells by transactivation assay
Agonist activity at Gal4-tagged human PPAR-gamma expressed in HEK cells by transactivation assay
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[PMID: 27326332] |
| HepG2 | EC50 |
>1.61 μM
Compound: 3; BMS-711939
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Agonist activity at full length human PPAR-gamma transfected in human HepG2 cells by luciferase reporter gene assay
Agonist activity at full length human PPAR-gamma transfected in human HepG2 cells by luciferase reporter gene assay
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[PMID: 27326332] |
| HepG2 | EC50 |
5 nM
Compound: 3; BMS-711939
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Agonist activity at full length human PPAR-alpha transfected in human HepG2 cells by luciferase reporter gene assay
Agonist activity at full length human PPAR-alpha transfected in human HepG2 cells by luciferase reporter gene assay
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[PMID: 27326332] |
化学情報
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CAS 番号 1000998-62-8
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分子量 462.86
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分子式 C22H20ClFN2O6
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SMILES
O=C(CN(CC1=CC(OCC2=C(C)OC(C3=CC=C(Cl)C=C3)=N2)=CC=C1F)C(OC)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BMS711939 関連分類
HY-115357 関連分類
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