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製品番号: HY-N13261

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Brickellin

Brickellin is an antioxidant agent that can be isolated from Varronia curassavica Jacq.. Brickellin inhibits advanced glycation end products (AGEs) formation, protein crosslinking, and oxidative damage to proteins. Brickellin can be used for the research of diabetes.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 90357-63-4
分子式: C₂₀H₂₀O₉
分子量:404.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Brickellin 構造式

CAS 番号: 90357-63-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
KB	ED₅₀	>25 μg/mL Compound: brickellin	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 1955888]
KB	ED₅₀	25 μg/mL Compound: brickellin	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 1955888]

体外実験

Brickellin (72 h) does not significantly inhibit the growth of KB cells in vitro, with an ED₅₀ value >25 μg/mL^[1].
Brickellin (0.031-0.125 mM; 8 days) significantly inhibits methylglyoxal-induced fluorescent advanced glycation end-product formation in bovine serum albumin in a concentration-dependent manner, with 0.125 mM brickellin reducing AGE formation by 60.8% on day 8^[2].
Brickellin (0.031-0.125 mM; 8 days) significantly reduces methylglyoxal-induced formation of dityrosine, N′-formylkynurenine, and kynurenine oxidation markers in bovine serum albumin in a concentration-dependent manner^[2].
Brickellin (0.031-0.125 mM; 8 days) inhibits methylglyoxal-induced protein carbonyl formation in bovine serum albumin after 8 days of incubation^[2].
Brickellin binds strongly to the SARS-CoV-2 Mpro predicted allosteric site^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 90357-63-4
分子量 404.37
分子式 C₂₀H₂₀O₉
SMILES

O=C1C(OC)=C(OC2=CC(OC)=C(OC)C(O)=C12)C=3C=C(OC)C(OC)=CC3O
Structure Classification
- Flavonoids
- Flavones
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Arisawa M, et al. Isolation and cytotoxicity of two new flavonoids from Chrysosplenium grayanum and related flavonols. J Nat Prod. 1991;54(3):898-901. [Content Brief]

[2]. Rodrigues WD, et al. In Vitro Antiglycation Potential of Erva-Baleeira (Varronia curassavica Jacq.). Antioxidants (Basel). 2023 Feb 19;12(2):522. [Content Brief]

[3]. Kubra B, Badshah SL, Faisal S, Sharaf M, Emwas AH, Jaremko M, Abdalla M. Inhibition of the predicted allosteric site of the SARS-CoV-2 main protease through flavonoids. J Biomol Struct Dyn. 2023 Oct-Nov;41(18):9103-9120. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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