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製品番号: HY-184363

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C14-306

C14-306 is an ionizable lipid with a linear 306 amine core and a C14 alkyl tail. C14-306 enhances brain transfection efficiency. Lipid nanoparticles (LNP) formulated with C14-306 promote mRNA delivery, increase neuronal transfection rate, and facilitate Cre-mediated recombination in the brain, while reducing off-target expression in the liver.

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CAS 番号: 2153563-36-9
分子式: C₆₃H₁₃₁N₃O₄
分子量:994.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

C14-306 構造式

CAS 番号: 2153563-36-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

LNPs formulated with C14-306 (60 ng mRNA/20,000 cells; 24 h) efficiently and specifically transfect the neuronal cell line SH-SY5Y in vitro, exhibit extremely low transfection activity toward the brain microvascular endothelial cell line hCMEC/D3, and induce high uptake by neuronal cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

LNPs formulated with C14-306 (0.4 mg/kg encapsulated mRNA; i.v.; single dose) (linear amine core, C14 tail) facilitate significantly enhanced mRNA delivery to the healthy mouse brain compared to shorter-tailed counterparts with the same core^[1].
LNPs formulated with C14-306 (0.35 mg/kg encapsulated mRNA; i.v.; single dose), particularly LNP 14, drive potent, liver-sparing mRNA transfection in the healthy Mus musculus brain, with efficacy far exceeding FDA-approved and benchmark LNPs^[1].
The C14-306-containing LNP 14 (0.35 mg/kg encapsulated mRNA; i.v.; single dose) does not induce BBB leakage, significant systemic inflammation, or liver enzyme elevation in healthy mice, demonstrating a favorable safety profile^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2153563-36-9
分子量 994.76
分子式 C₆₃H₁₃₁N₃O₄
SMILES

OC(CN(CCCN(C)CCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CCCCCCCCCCCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Han EL, et al. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS nano. 2026 Feb 03;20(4):3807-3820. [Content Brief]

[2]. Bhunia S M, Bhattacharjee A, Saha P, et al. Lipid Nanoparticles for Overcoming Biological Barriers to mRNA Delivery to the Brain[J].

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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