C18-Ceramide
Based on 1 Customer Validation
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 2304-81-6
- 分子式: C36H71NO3
- 分子量:565.95
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
In the PC12 cell capacitance measurement experiment, C18-Ceramide (d18:1/18:0) (2 μM; transient) can significantly increase the cell membrane capacitance, indicating that it can promote exocytosis[1].
In the PC12 cell total internal reflection fluorescence microscopy (TIRFM) experiment, C18-Ceramide (d18:1/18:0) (2 μM) can rapidly reduce the number of NPY-EGFP-labeled subcellular membrane vesicles, which undergo endocytosis by fusing with the cell membrane[1].
In U251 and A172 glioma cells, C18-Ceramide (d18:1/18:0) (20 μM; 48 h) inhibits glioma cell viability and induces cell death[2].
C18-Ceramide (d18:1/18:0) (20 μM; 48 h) activates endoplasmic reticulum stress and increases the mRNA and protein levels of ATF-4, XBP-1 (s) and CHOP[2].
C18-Ceramide (d18:1/18:0) induced lethal autophagy, increased the punctate distribution and density of GFP-LC3, promoted the conversion of LC3B-I to LC3B-II and decreased the level of p62[2].
C18-Ceramide (d18:1/18:0) inhibited the PI3K/AKT pathway and decreased the expression levels of PI3K and p-AKT (S473)[2].
C18-Ceramide (d18:1/18:0) (20μM; co-treatment with VM-26 for 48h) increased the chemosensitivity of U251 and A172 cells to VM-26 (HY-13761), synergistically inhibited cell growth, and induced more apoptosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U251, A172 glioma cells
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Concentration:20 μM
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Incubation Time:48 h
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Result:Inhibited ell viability and induced cell death.
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Cell Line:U251, A172 glioma cells
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Concentration:20 μM
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Incubation Time:48 h
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Result:Increased the mRNA and protein levels of ATF-4, XBP-1(s), and CHOP.
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Cell Line:U251, A172 glioma cells
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Concentration:20 μM
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Incubation Time:48 h
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Result:Inhibited the expression levels of PI3K and p-AKT(S473).
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Cell Line:U251, A172 glioma cells
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Concentration:20μM (C18-Ceramide), with 0.25 μM VM-26 for U251 cells, or 10 μM VM-26 for A172 cells
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Incubation Time:48 h
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Result:Combined with VM-26, inhibited cell growth synergistically, and induced more apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2304-81-6
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性状 Solid
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分子量 565.95
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分子式 C36H71NO3
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
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別名
C18-Ceramide
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
Ethanol : 5 mg/mL (8.83 mM; Need ultrasonic)
DMF : 1 mg/mL (1.77 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tang N, et al. Differential effects of ceramide species on exocytosis in rat PC12 cells. Exp Brain Res. 2007 Nov;183(2):241-7. [Content Brief]
[2]. Wang Z, et al. Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma. Oncotarget. 2017 Oct 23;8(61):104022-104036. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / Ethanol | 1 mM | 1.7669 mL | 8.8347 mL | 17.6694 mL | 44.1735 mL |
| Ethanol | 5 mM | 0.3534 mL | 1.7669 mL | 3.5339 mL | 8.8347 mL |
C18-Ceramide (d18:1/18:0) 関連分類
HY-100355 関連分類
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