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United States

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製品番号: HY-189746

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CBD-TSC1

CBD-TSC1 is a reversible mixed-type inhibitor of human and mushroom tyrosinase, with an IC₅₀ of 27.72 μM against mushroom tyrosinase. CBD-TSC1 interacts with both the free enzyme and the enzyme-substrate complex. CBD-TSC1 reduces intracellular reactive oxygen species (ROS) levels under oxidative stress as well as melanin content in zebrafish larvae.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₃H₃₃N₃O₂S
分子量:415.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CBD-TSC1 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

mushroom Tyrosinase

27.72 μM (IC₅₀)

体外実験

CBD-TSC1 (5-20 μM; 8-24 h) maintains the viability of G361 melanoma cells and HaCaT keratinocytes above 70%^[1].
CBD-TSC1 (0.625-2.5 μM; 24 h pre-incubation) reduces H₂O₂-induced intracellular ROS in HaCaT and G361 cells, with a significant reduction at 2.5 μM^[1].
CBD-TSC1 (0-75 μM) inhibits human tyrosinase diphenolase activity in G361 melanoma cell lysates with an IC₅₀ of 34.47 μM and acts as a mixed-type inhibitor with a K_i of 26.96 μM^[1].
CBD-TSC1 inhibits mushroom tyrosinase diphenolase with an IC₅₀ of 27.72 μM, and as a reversible mixed-type inhibitor, it prolongs the lag phase of monophenolase by 5.5 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

G361 human melanoma cells and HaCaT human keratinocytes
Concentration:

5 μM; 10 μM; 15 μM; 20 μM
Incubation Time:

8, 12, 24 h
Result:

At short-term exposure (up to 24 h), CBD-TSC1 was well tolerated in both cell lines, with viability remaining above 70% across all tested concentrations.
These findings indicate that CBD-TSC1 exhibited low acute cytotoxicity under the tested conditions and showed a comparable or slightly improved tolerability profile relative to CBD during the initial 12 h of exposure.

Related Protocols :

ROS/oxidative-stress fluorescent staining

化学情報

分子量 415.59
分子式 C₂₃H₃₃N₃O₂S
SMILES

CC1=C[C@@H](C2=C(O)C=C(CCCCC)C(/C=N/NC(N)=S)=C2O)[C@H](C(C)=C)CC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Shabat-Simon M, et al. Cannabidiol-thiosemicarbazone exhibits dual tyrosinase inhibition and antioxidant activity in human skin-derived cells. Bioorganic & medicinal chemistry letters. 2026 Oct;139:130707.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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