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製品番号: HY-D3180

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CDr20

Name: CDr20
Brand: MedChemExpress
SKU: HY-D3180
Price: 436.00 USD
Availability: InStock
Rating: 5 (1 reviews)

CDr20 is a fluorescent chemical probe capable of crossing the blood-brain barrier. CDr20 undergoes glucuronidation catalyzed by the UDP-glucuronosyltransferase Ugt1a7c, which triggers a fluorescence turn-on response. CDr20 enables visualization of live microglial cells. CDr20 can be used for research on Alzheimer's disease, stroke, and autism.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1201643-01-7
分子式: C₁₉H₁₇BF₂N₂O₂
分子量:354.16

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Please store the product under the recommended conditions in the Certificate of Analysis.

CDr20 構造式

CAS 番号: 1201643-01-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CDr20 specifically labels mouse primary microglia in mixed glial cultures, with 97.3% colocalization with the microglial marker Iba-1, and minimal to no labeling of astrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

CDr20 specifically labels 94.1-99.2% of microglia in live mouse brain slices, whole embryos, and intact living mouse brains (including inflammatory and Alzheimer's disease models) via a Ugt1a7c-mediated fluorescence turn-on mechanism^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

化学情報

CAS 番号 1201643-01-7
分子量 354.16
分子式 C₁₉H₁₇BF₂N₂O₂
SMILES

[F-][B+3]1([N]2=CC=CC2=CC3=C(C)C=C([N-]31)/C=C/C4=CC=C(C(O)=C4)OC)[F-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kim B, et al. Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate. Angew Chem Int Ed Engl. 2019;58(24):7972-7976. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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