CGP36216
CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 123691-29-2
- 分子式: C5H14NO2P
- 分子量:151.14
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
GABAB receptor[1]
CGP36216 is ineffective at GABA postsynaptic receptors, it is appreciably more active at presynaptic receptors[2].
CGP36216 (100 µM) could increase the frequency of spontaneous firing in VTA-DA neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[3].
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Dosage:20 μg/Rat.
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Administration:Intra-VTA injection (ventral tegmental area).
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Result:Abolishes CPP induced by intra-VTA injection of morphine.
化学情報
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CAS 番号 123691-29-2
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分子量 151.14
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分子式 C5H14NO2P
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SMILES
O=P(CC)(CCCN)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[2]. J Ong, et al. CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415(2-3):191-5. [Content Brief]
[3]. Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CGP36216 関連分類
HY-103518 関連分類
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