Chrysophanein
Based on 1 publication(s) in Google Scholar
Chrysophanein is a chrysophanol glycoside from leaves and roots of Aloe hijazensis. Chrysophanein shows a moderate cytotoxic activity against several carcinoma cells lines.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.08%
- CAS 番号: 4839-60-5
- 分子式: C21H20O9
- 分子量:416.38
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Chrysophanein
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | ED50 |
>5 μg/mL
Compound: chrysophanein
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Cytotoxicity against HUVEC
Cytotoxicity against HUVEC
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[PMID: 15043409] |
| LNCaP | ED50 |
>5 μg/mL
Compound: chrysophanein
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 15043409] |
| Lu1 | ED50 |
>5 μg/mL
Compound: chrysophanein
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Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
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[PMID: 15043409] |
| MCF7 | ED50 |
>5 μg/mL
Compound: chrysophanein
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 15043409] |
化学情報
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CAS 番号 4839-60-5
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性状 Solid
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分子量 416.38
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分子式 C21H20O9
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Color Light yellow to orange
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SMILES
O=C(C1=CC=CC(O)=C1C2=O)C3=C2C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO)=CC(C)=C3
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Ethnopharmacol
Chrysophanein of Rhubarb rescues ILC3-Derived IL-22 by blocking CCDC25/ILK/HIF-1α for mucosal healing in ulcerative colitis mice. [Abstract]2025 Sep 22;355(Pt A):120628. PMID: 40992441
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (240.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4017 mL | 12.0083 mL | 24.0165 mL | 60.0413 mL |
| 5 mM | 0.4803 mL | 2.4017 mL | 4.8033 mL | 12.0083 mL | |
| 10 mM | 0.2402 mL | 1.2008 mL | 2.4017 mL | 6.0041 mL | |
| 15 mM | 0.1601 mL | 0.8006 mL | 1.6011 mL | 4.0028 mL | |
| 20 mM | 0.1201 mL | 0.6004 mL | 1.2008 mL | 3.0021 mL | |
| 25 mM | 0.0961 mL | 0.4803 mL | 0.9607 mL | 2.4017 mL | |
| 30 mM | 0.0801 mL | 0.4003 mL | 0.8006 mL | 2.0014 mL | |
| 40 mM | 0.0600 mL | 0.3002 mL | 0.6004 mL | 1.5010 mL | |
| 50 mM | 0.0480 mL | 0.2402 mL | 0.4803 mL | 1.2008 mL | |
| 60 mM | 0.0400 mL | 0.2001 mL | 0.4003 mL | 1.0007 mL | |
| 80 mM | 0.0300 mL | 0.1501 mL | 0.3002 mL | 0.7505 mL | |
| 100 mM | 0.0240 mL | 0.1201 mL | 0.2402 mL | 0.6004 mL |
Chrysophanein 関連分類
HY-N4151 関連分類
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