CKD-731
CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 251111-15-6
- 分子式: C28H38O8
- 分子量:502.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CPAE | IC50 |
0.00003 ng/mL
Compound: 3d
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Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
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[PMID: 10636239] |
| CPAE | IC50 |
0.03 μg/mL
Compound: S10
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Cytotoxic activity against cow CPAE cells by MTT assay
Cytotoxic activity against cow CPAE cells by MTT assay
|
[PMID: 31009908] |
| EL4 | IC50 |
0.00015 ng/mL
Compound: 3d
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Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
|
[PMID: 10636239] |
| EL4 | IC50 |
0.15 μg/mL
Compound: S10
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Antitumor activity against mouse EL4 cells by MTT assay
Antitumor activity against mouse EL4 cells by MTT assay
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[PMID: 31009908] |
| P388 | IC50 |
>1 ng/mL
Compound: 3d
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Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
|
[PMID: 10636239] |
化学情報
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CAS 番号 251111-15-6
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分子量 502.60
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分子式 C28H38O8
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SMILES
O=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)/C=C/C4=CC(OC)=C(OC)C(OC)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CKD-731 関連分類
HY-103653 関連分類
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