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製品番号: HY-P11948

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c-Myc NLS

c-Myc NLS is a non-canonical nuclear localization signal (NLS) derived from the oncoprotein c-Myc, with the sequence PAAKRVKLD and containing 3 basic amino acids. c-Myc NLS mediates the nuclear localization of fusion proteins, and all its regions are essential or play important roles in nuclear import. c-Myc NLS can target fused pyruvate kinase to the nuclei of transfected cells.

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CAS 番号: 253328-16-4
分子式: C₄₄H₈₀N₁₄O₁₂
分子量:997.19

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

c-Myc NLS 構造式

CAS 番号: 253328-16-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

c-Myc NLS directs recombinant chicken pyruvate kinase to localize in the nuclei of transfected COS7 cells, in which the upstream PAA tripeptide and downstream LD dipeptide play critical or important roles in efficient nuclear localization^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 253328-16-4
分子量 997.19
分子式 C₄₄H₈₀N₁₄O₁₂
SMILES

O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]1NCCC1
配列

Pro-Ala-Ala-Lys-Arg-Val-Lys-Leu-Asp
シーケンスの短縮

PAAKRVKLD
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Makkerh JP, et al. Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids. Current biology : CB. 1996 Aug 01;6(8):1025-7. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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