country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-130012

Copy Link Print Information

CO23

Name: CO23
Brand: MedChemExpress
SKU: HY-130012
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.00%
CAS 番号: 1370363-74-8
分子式: C₁₉H₁₈I₂N₂O₄
分子量:592.17

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CO23 構造式

CAS 番号: 1370363-74-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体内実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation^[1].

IC₅₀ & Target

TRα^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	11 nM Compound: CO23	Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay	[PMID: 17988877]
HeLa	EC₅₀	58 nM Compound: CO23	Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay	[PMID: 17988877]
U2OS	EC₅₀	34 nM Compound: CO23	Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay	[PMID: 17988877]
U2OS	EC₅₀	390 nM Compound: CO23	Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay	[PMID: 17988877]

体内実験

CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hypothyroid Wistar rats^[1]
Dosage:

0.04, 0.8, 2.5, and 5.0 nmol/g
Administration:

Ip
Result:

Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.

化学情報

CAS 番号 1370363-74-8
性状 Solid
分子量 592.17
分子式 C₁₉H₁₈I₂N₂O₄
Color Off-white to light yellow
SMILES

O=C1NC(C(CC2=CC(I)=C(OC3=CC=C(O)C(C(C)C)=C3)C(I)=C2)N1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All

Sort by:

Journal Impact Factor

Drug Metab Dispos

Metabolic flux analysis of bile acid biosynthesis acidic pathway in HepG2 cells reveals CYP8B1 inhibition of azole antifungals. [Abstract]

2025 Nov;53(11):100168. PMID: 41124962

溶剤 & 溶解度

体外:

DMSO : 250 mg/mL (422.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6887 mL

8.4435 mL

16.8870 mL

5 mM

0.3377 mL

1.6887 mL

3.3774 mL

10 mM

0.1689 mL

0.8444 mL

1.6887 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Grijota-Martínez C, et al. In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23on rat liver, heart, and brain. Endocrinology. 2011 Mar;152(3):1136-42. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6887 mL	8.4435 mL	16.8870 mL	42.2176 mL
	5 mM	0.3377 mL	1.6887 mL	3.3774 mL	8.4435 mL
	10 mM	0.1689 mL	0.8444 mL	1.6887 mL	4.2218 mL
	15 mM	0.1126 mL	0.5629 mL	1.1258 mL	2.8145 mL
	20 mM	0.0844 mL	0.4222 mL	0.8444 mL	2.1109 mL
	25 mM	0.0675 mL	0.3377 mL	0.6755 mL	1.6887 mL
	30 mM	0.0563 mL	0.2815 mL	0.5629 mL	1.4073 mL
	40 mM	0.0422 mL	0.2111 mL	0.4222 mL	1.0554 mL
	50 mM	0.0338 mL	0.1689 mL	0.3377 mL	0.8444 mL
	60 mM	0.0281 mL	0.1407 mL	0.2815 mL	0.7036 mL
	80 mM	0.0211 mL	0.1055 mL	0.2111 mL	0.5277 mL
	100 mM	0.0169 mL	0.0844 mL	0.1689 mL	0.4222 mL

Bioz

Keywords

CO23

1 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

CO23

Resmetirom

Sobetirome

Eprotirome

Reverse T3

MB-07811

PCO371

NH-3

Reverse T3 (Standard)

3,5-Diiodothyropropionic acid

DS08210767

Liothyronine sodium

Methimazole

MedChemExpress（MCE）の使用を引用している文献 CO23

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

CO23

Resmetirom

Sobetirome

Eprotirome

Reverse T3

MB-07811

PCO371

NH-3

Reverse T3 (Standard)

3,5-Diiodothyropropionic acid

DS08210767

Liothyronine sodium

Methimazole

MedChemExpress（MCE）の使用を引用している文献 CO23

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

CO23 関連分類

HY-130012 関連分類

Bioz