CP-288886
CP-288886 is a cysLT1 receptor antagonist with a Ki value of 0.004 μM. CP-288886 exhibits comparable activity to Zafirlukast (HY-17492) and Pranlukast (HY-B0290). CP-288886 inhibits calcium mobilization with an IC50 of 0.0005 μM in human U937 cells. CP-288886 has high oral bioavailability. CP-288886 possesses anti-asthmatic activity in a guinea pig asthma model and can be used for the research of diseases such as asthma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 221332-74-7
- 分子式: C30H28ClF3N2O6S
- 分子量:637.07
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
CysLT1 0.004 μM (Ki) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
0.0005 μM
Compound: 7
|
Compound was tested for its ability to inhibit calcium influx in human U937 cells
Compound was tested for its ability to inhibit calcium influx in human U937 cells
|
[PMID: 9934474] |
化学情報
-
CAS 番号 221332-74-7
-
分子量 637.07
-
分子式 C30H28ClF3N2O6S
-
SMILES
O[C@H]1C2=CC(OCC3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2OC(C)(C)[C@H]1CC5=C(C=CC(NS(C(F)(F)F)(=O)=O)=C5)OC
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CP-288886 関連分類
HY-105358 関連分類
Powered by Bioz