CR 665
Based on 2 publication(s) in Google Scholar
CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.66%
- CAS 番号: 228546-92-7
- 分子式: C36H49N9O4
- 分子量:671.83
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 CR 665
MoreOpioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
C50: 10.9 nM (κ-opioid)[1]
CR 665 exhibits high peripheral to central nervous system (CNS) selectivity[1].
CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 228546-92-7
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性状 Solid
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分子量 671.83
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分子式 C36H49N9O4
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Color White to off-white
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別名
JNJ 38488502; FE 200665
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons. [Abstract]2025 Dec 24;188(26):7547-7570.e45 PMID: 41406962 -
溶剤 & 溶解度
DMSO : 100 mg/mL (148.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Anne E Olesen, et al. A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone. Clin Pharmacokinet [Content Brief]
[2]. Francis M Hughes Jr, et al. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013 Nov 4;7:16-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4885 mL | 7.4424 mL | 14.8847 mL | 37.2118 mL |
| 5 mM | 0.2977 mL | 1.4885 mL | 2.9769 mL | 7.4424 mL | |
| 10 mM | 0.1488 mL | 0.7442 mL | 1.4885 mL | 3.7212 mL | |
| 15 mM | 0.0992 mL | 0.4962 mL | 0.9923 mL | 2.4808 mL | |
| 20 mM | 0.0744 mL | 0.3721 mL | 0.7442 mL | 1.8606 mL | |
| 25 mM | 0.0595 mL | 0.2977 mL | 0.5954 mL | 1.4885 mL | |
| 30 mM | 0.0496 mL | 0.2481 mL | 0.4962 mL | 1.2404 mL | |
| 40 mM | 0.0372 mL | 0.1861 mL | 0.3721 mL | 0.9303 mL | |
| 50 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7442 mL | |
| 60 mM | 0.0248 mL | 0.1240 mL | 0.2481 mL | 0.6202 mL | |
| 80 mM | 0.0186 mL | 0.0930 mL | 0.1861 mL | 0.4651 mL | |
| 100 mM | 0.0149 mL | 0.0744 mL | 0.1488 mL | 0.3721 mL |
CR 665 関連分類
HY-P3609 関連分類
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