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製品番号: HY-100413

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CS-526

CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H⁺,K⁺-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 313272-12-7
分子式: C₂₀H₂₂FN₃O
分子量:339.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CS-526 構造式

CAS 番号: 313272-12-7

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価格（税別）

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CS-526 (0-100 µM; 60 min) inhibits H⁺, K⁺-ATPase and Na⁺, K⁺-ATPase activity in a dose-dependent manner with IC₅₀ values of 61 nM, 10.4 µM, respectively^[1].
CS-526 competitive binds to K⁺ binding site of H⁺, K⁺-ATPase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) inhibits gastric acid secretion in a dose-dependent manner in pylorus-ligated rats^[1].
CS-526 (1, 3, 10, 30 mg/kg; intrapouch; 180 min) dose-dependently inhibits the histamine-induced gastric acid secretion in the Heidenhain pouch dogs^[1].
CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) prevents esophageal lesions and acute gastric mucosal lesions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pylorus-Ligated Rats^[1]
Dosage:

1, 3, 10, 30 mg/kg
Administration:

Intraduodenal administration or p.o.
Result:

Dose-dependently inhibited gastric acid secretion with ID₅₀ values of 2.8, 0.7 mg/kg for intraduodenal administration and oral administration, respectively.

Animal Model:

Reflux Esophagitis Model in Rats^[1]
Dosage:

1, 3, 10 mg/kg
Administration:

Intraduodenal administration or p.o.
Result:

Significantly reduced the lesion scores with ID₅₀ values of 5.4, 1.9 mg/kg for intraduodenal and p.o. respectively.

化学情報

CAS 番号 313272-12-7
分子量 339.41
分子式 C₂₀H₂₂FN₃O
SMILES

C[C@@H]1[C@@H](CN2C(C)=C(C)C3=C2C(OCC4=CC=C(F)C=C4)=NN=C3)C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ito K, et al. Pharmacological profile of novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526). J Pharmacol Exp Ther. 2007 Oct;323(1):308-17. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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